Comparison of itraconazole and ketoconazole in the treatment of experimental candidal vaginitis.
نویسندگان
چکیده
Comparison of itraconazole (R51,211) and ketoconazole in the treatment of experimental candidal vaginitis in rats on schedules of 3 and 5 days revealed significantly superior results with itraconazole at all dosages (1.0 to 7.5 mg/kg) studied, but was particularly evident at 1.0 and 2.5 mg/kg. A single 25-mg/kg dose of itraconazole was as effective as 5 daily 5-mg/kg doses of itraconazole.
منابع مشابه
Activity of SM-4470, a new imidazole derivative, against experimental fungal infections.
The antifungal activity of orally active SM-4470, (R)-3-(n-butylthio)-2-(2,4-dichlorophenyl)-1-(imidazole-1-yl)-2-propanol hydrochloride, was compared with that of ketoconazole. SM-4470 showed twofold-higher activity than ketoconazole in the oral treatment of systemic infection with Candida albicans in mice. In addition, SM-4470 was effective against aspergillosis in mice, but ketoconazole was ...
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متن کاملAntifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 26 2 شماره
صفحات -
تاریخ انتشار 1984